I: CLINICAL STUDIES
51976703111 ;
11/08/01 15:40; Jedax #373
owners far removed from a veterinary facility Thus dogs from literal1y anywhere in the world could be entered into a study utilizing Holter recordings.
Objectives:
1 To determine the incidence and frequency of premature ventJ:"icular
contractions in asymptomatic Doberman Pinschers.
2 To determine the relation betWeen geographic region and the incidence and
fTequency of premature ventricular contractions in asymptomatic Dobennan
Pinschers.
3. To detennine the relation between age, coat color, and gender and the
incidence and frequency of premature ventricular contractions in
asymptomatic Doberman Pinschers.
4. To detennine the range of nonnaIity for heart rate variability and the signal
average ECG for asymptomatic Doberman Pinschers.
5. By following these dogs for the rest of their lives to determine:
. The frequency of premature ventricular contractions that predict dogs
destined to develop OCM or sudden death.
. The level. of abnormality of heart rate variability that predicts dogs
destined to develop OCM or sudden death
. The level of abnormality of the signal average ECG that predicts dogs
destined to develop DCM or sudden death.
6. To investigate newer therapies that have the potential to abort or retard the
progression of occult DCM in the asymptomatic Doberman Pinscher.
7. To investigate newer therapies that have the potential to reduce the
incidence of sudden death.
Experimental Design:
This is a long-tenn study. We are familiar with such long-term efforts as. demonstrated by our activities for the last 10 years of work with the natural history of OCM in Doberman Pinschers. We propose to identify small groups of asymptomatic Dobermans with owners that are willinS to allow us to Holter their dogs at least annually on a long-tenn basis. The principal contact person for each group will receive a videotape instructing them on the proper placement of the Holter recorder. a Holter recorder. cassette tape and battery. This person will then arTange to have the Holter placed on each dog in the group on successive days. A new cassette tape and battery will be required on each dog. After each dog in the group has been taped. the collection of tapes, the Holter recorder, and the video will be returned. The tapes will be analyzed in batches, owners of dogs will receive a report, the Holter recorders and videotapes will be mailed onto the next group. We propose to begin with 10 Holter recorders and add more as demand increases. Presently, we have been contacted by groups throughout North America, Europe, South America and AustralialNew Zealand interested in participating.
As some of these dogs will ultimately go onto develop overt congestive heart failure (CHF) or sudden death (SD), prospectively we will be able to determine the frequency and type of premature ventricul~r contractions that were detected on the examinations prior to these endpoints (CHF or SD) and the time to these endpoints